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sherkahn
Diamond Bar, SGV, LA, CA
Pomona, Inland Empire, CA Today!
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Locked. No further comments permitted.Astrazeneca Vaccine on Hold
Sep 9 2020 08:44AM more by sherkahn
Tags: Current Events

This is what happens when you rush things.


AstraZeneca on Tuesday temporarily halted its phase three trials of a possible coronavirus vaccine after one participant suffered what may have been a serious adverse reaction. The vaccine "candidate" was developed by the pharmaceutical giant along with Oxford University and is currently being tested in large-scale human trials in the U.K., the U.S., Brazil and South Africa.
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Just a spoon full of sugar makes the medicine
      
There are 42 comments on this blog. This blog is locked and no further comments are permitted.
ocguy66
OC, CA
45 blogs/1904 comments
since Apr 26 2006

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Sep 9 2020 09:27AM     link to this

I’m taking the Russian vaccine
Night-Rider
OC, CA
71 blogs/5312 comments
since Jul 23 2019

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Sep 9 2020 09:43AM     link to this

Someone may have developed transverse myelitis. This is an inflammation of the spinal cord that can interfere with signaling. Can have things like weakness and paralysis. Could be temporary or permanent.

Doesn’t sound good for that vaccine if it indeed was the cause. Again, most vaccine candidates fail. We’ll be lucky to find a safe, effective one to be given out sometime next year.

This is why we need to test for safety and efficacy. No one wants to become paralyzed from a vaccine.
Night-Rider
OC, CA
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since Jul 23 2019

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Sep 9 2020 09:50AM     link to this

Transverse myelitis is one of those symptoms that can herald in multiple sclerosis.
loucfirr1
LA, CA
212 blogs/26584 comments
since Jun 29 2008

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Sep 9 2020 10:22AM     link to this

The sad part is that this news probably made you giddy.
Night-Rider
OC, CA
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Sep 9 2020 10:24AM     link to this

Nope
MMarblez
CA
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since Apr 8 2018

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Sep 9 2020 10:59AM     link to this

It is not rushing things you fucking idiot - it is how clinical trials work.

They just have to report it since it is in the public eye.

Billions are spent on therapy that get to Phase 2 or 3 then die - or they are found to have a completely different use - like all those psoriasis meds - they all start as cancer trials.

Fuck I hate stupid people that think they know about shit - stick to all the bullshit political stuff.
typeA4play
OC, CA
2 blogs/54 comments
since Feb 25 2007

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Sep 9 2020 11:16AM     link to this

The adverse event is not because it was rushed!

This is why clinical trials are done. The event needs to be studied as with all adverse events to determine if the vaccine was the cause.

Wish everyone would stop with the vaccine gloom and doom. These vaccines are based on existing technology by their respective developers so they already know a lot about how the drug interacts with the human body. That is one of the reasons these vaccines were developed so fast.

InsearchofStarfish
Santa Ana, OC, CA
741 blogs/13135 comments
since Nov 17 2008

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Sep 9 2020 11:42AM     link to this

it's kinda hard to listen to him...one minute he has this smart thing, about the virus, going...next minute, he's a revolutionary against trump. it's pretty herky-jerky


CUMAlot
Huntington Beach, OC, CA
11 blogs/412 comments
since Jun 3 2009

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Sep 9 2020 01:27PM     link to this

This is just a speed bump and they are being cautious. We will get more info in due time. I hope it turns out to be a false issue.
Quat
Santa Monica, LA, CA
3 blogs/566 comments
since Jul 19 2017

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Sep 9 2020 01:51PM     link to this

Absolutely ridiculous to speculate about the cause and significance of the adverse effect at this point.
Angler1
CA
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since Jan 6 2008

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Sep 9 2020 02:01PM     link to this

Read carefully, MAYBE, MIGHT, They dont know if the vaccine is the cause.
Night-Rider
OC, CA
71 blogs/5312 comments
since Jul 23 2019

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Sep 9 2020 02:36PM     link to this

Absolutely not ridiculous to speculate. There’s really not much to this. If they can’t unlink the transverse myelitis to the vaccine, you don’t continue the trial. You go to the next vaccine.
Night-Rider
OC, CA
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Sep 9 2020 02:46PM     link to this

There are hundreds of vaccine candidates. This why it takes so long to bring a vaccine into use. Five years at least, usually.
Night-Rider
OC, CA
71 blogs/5312 comments
since Jul 23 2019

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Sep 9 2020 02:49PM     link to this

There are 45 vaccine candidates currently in Phase 1-3.
Redwood
San Diego, CA
10 blogs/84 comments
since Jan 7 2008

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Sep 9 2020 05:04PM     link to this

This is what happens when you “chicken little” Sherkan. Relax dude

Peanuts cause adverse reactions in numerous people. Why haven’t peanuts been put on a federal ban? Difficulty breathing, hives, wheezes, anaphylactic shock...not treated early enough....DEATH!! Peanuts KILL!!
Quat
Santa Monica, LA, CA
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Sep 9 2020 06:13PM     link to this

@NR - it's best to wait for an official diagnosis before offer your expert medical opinions about vaccines and adverse reactions. I didn't know you are both an Internet virologist and neurologist. Must be keeping pretty busy these days.

It is a big deal if the Oxford vaccine doesn't work out since there was a large investment in scaling up production so the vaccine would be available immediately upon approval. Probably over a billion dollars and they have probably already made millions of doses. Typically, one doesn't invest large sums UNTIL a vaccine or product has been approved by regulators. Investments were also made in the two other vaccines in Phase III trials. So, if there is a year or more delay because your top 3 candidates aren't safe and effective that is many lives that will be lost. I know this because I deal with this stuff every day.
Redwood
San Diego, CA
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since Jan 7 2008

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Sep 9 2020 06:20PM     link to this

A single adverse reaction to a vaccine does not make it a “failed vaccine”. If a single “adverse reaction” makes it a failure, you can now argue the ban of peanuts. Not only can you argue the ban of peanuts, but you can then argue the ban of medications for the treatment of an allergic reaction to peanuts. An “adverse reaction” to both epinephrine and benadryl is death. So now, we have to ban peanuts, epinephrine and benadryl based off the OP’s reasoning of a singular adverse reaction to a single drug
Night-Rider
OC, CA
71 blogs/5312 comments
since Jul 23 2019

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Sep 9 2020 06:43PM     link to this

@Quat If you actually followed the information closely, you would know I didn't make a preliminary diagnosis, the experts have. And this was a SECOND case of someone with symptoms of transverse myelitis. Not the first one. The first case happened earlier in a patient later diagnosed with multiple sclerosis per STAT, so it was deemed unrelated. This second case needs to play out to see if the preliminary diagnosis sticks or if something else is in play. This fits exactly with what I have stated up to this point.

It was foolish to invest so much in vaccines so early because the typical pattern of vaccines is most don't work out. Why would we have expected anything different for coronavirus? I would not try to salvage a vaccine that isn't looking effective or safe because we spent foolishly. That would also be foolish.
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More information about the diagnosis of TM
Night-Rider
OC, CA
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Sep 9 2020 06:52PM     link to this

We are clearly rushing things way too fast. Not because there was an adverse effect -- that was to be expected -- but because most vaccines will fail, and our system locked into rewarding 3 vaccines way too early.

File under "too big to fail" all over again.
Night-Rider
OC, CA
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since Jul 23 2019

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Sep 9 2020 07:08PM     link to this

The silver lining is 7 vaccines have made it to phase 3. And statistically speaking, 40% of vaccines that make it to phase 3 make it. So we will likely get 3 vaccines out of the 7. It probably won't be the three we stupidly bet on though.
MMarblez
CA
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Sep 9 2020 09:28PM     link to this

What illustrates rushing?

Another idiot who knows nothing of medical science and clinical trials.

Putting all of you assets on a project means you have the ability to move more quickly in research. It goes as fast as the genetic trail allows you. And this project began with a huge cache of data. The job is to tweak already available concepts - not starting at ground zero.

GoBallsDeep
Fullerton, OC, CA
152 blogs/11237 comments
since Dec 12 2019

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Sep 9 2020 10:02PM     link to this

You guys are finally figuring out Fishy's "smartest scientist in the world" act.

The guy is no idiot but he's definitely an epic fail


GoBallsDeep
Fullerton, OC, CA
152 blogs/11237 comments
since Dec 12 2019

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Sep 9 2020 10:13PM     link to this

Here's the bottom line:

OP loves bringing the gloom, the more people dying the better cause it's all DJT's fault anyway
Fishy thinks he should be in charge of the CDC, NIH & HHS all at the same time
In a global pandemic, you fight with the weapons you got even if they're not perfect
Plasma, dexamethasone, HCQ, tocilizumab, whatever
There's nothing unusual or rushed about this Phase 3
Shit happens in trials
Next!
GoBallsDeep
Fullerton, OC, CA
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Sep 9 2020 10:17PM     link to this

Btw, heard that it was Dumb Doofy got the myelitis
That's why he's been AWOL
Thank you cards may be sent directly to
Astrazeneca
Covid 19 trials
Gracie Mansion
NY, NY
Night-Rider
OC, CA
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Sep 9 2020 10:28PM     link to this

"The job is to tweak already available concepts - not starting at ground zero."

Of course, and all the vaccines that are in phase 3 are doing that. It's just that we invested too quickly in project warp speed by upscaling production of (and the money that's spent in doing so) 3 out of 7 of them, and we easily could have guessed on the wrong 3. That's called rushing.
GoBallsDeep
Fullerton, OC, CA
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Sep 9 2020 10:31PM     link to this

Whatever you say, EL Presidente.
GoBallsDeep
Fullerton, OC, CA
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Sep 9 2020 10:34PM     link to this

If your 40% is accurate, then 1 should be a winner....possibly 2
Math is science too.
MMarblez
CA
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Sep 9 2020 10:59PM     link to this


You still do not understand how this shit works. It is all about data, collecting it, sharing it then using it to make changes as you go.

You always invest most in protocols that have most promise. Nobody else is lacking anything - the data is shared so whoever runs their trials, etc. best will be looked at first. When the target changes or outcomes negative you fucking pivot with the data you gathered.



Night-Rider
OC, CA
71 blogs/5312 comments
since Jul 23 2019

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Sep 9 2020 11:12PM     link to this

That sounds more like a general statement about business than an answer to the specific problem of waste I brought up.
AFMadness
Inland Empire, CA
264 blogs/5900 comments
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Sep 9 2020 11:18PM     link to this

Predicted BIO-weapon Release Years Ago: Learn Whats Next
.
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Predicted BIO-weapon Release Years Ago: Learn Wha
Night-Rider
OC, CA
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Sep 9 2020 11:24PM     link to this

I guess what you can help me understand is if you have a bunch of vaccines, and 3 are clearly at the most advanced stage of development, why is it good to go all out on the top 3 and even invest in bringing the product to the buyer before you see all the safety and efficacy data on these top 3? Wouldn’t you want to invest only in the 3 phases of development? I guess if you were trying to rush things out you would do it this way, but it’s so hasty and wasteful because we know a priori most vaccine products don’t end up working.
Night-Rider
OC, CA
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Sep 10 2020 12:09AM     link to this

Here's a look at other vaccines out there, aside from the top 3, and how scientists are trying to get their vaccine developed without being part of operation warp speed.

An interesting one is an intranasal vaccine, which should end up giving strong immunity inside airways, which is important in a disease that works particularly there.
Night-Rider
OC, CA
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Sep 10 2020 12:09AM     link to this

oops. fail. Here's the link.
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https://www.nature.com/articles/d41586-020-02583-z
Night-Rider
OC, CA
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Sep 10 2020 12:23AM     link to this

It's more like you want a system where you can hedge your bets rather than invest fully in only 3 candidates when the success rate is low.
Angler1
CA
90 blogs/5963 comments
since Jan 6 2008

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Sep 10 2020 01:11AM     link to this

nr, please go back and play with your car, kit.
Every response you make is confirming what a nutjob you are...
KaiserSoce
CA
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since Oct 2 2017

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Sep 10 2020 05:48AM     link to this

We are all going to die. Sorry. Well... not really.
KaiserSoce
CA
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Sep 10 2020 05:55AM     link to this

By the way... I have it on good authority that the adverse reaction was actually accelerated toe nail growth. The damage caused to shoes, socks, pantyhose and breadsticks makes the vaccine 💉 not cost effective.

jazz51
Laguna Hills/Woods, OC, CA
258 blogs/12871 comments
since Sep 24 2008

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Sep 10 2020 07:59AM     link to this

Yes, let's all celebrate that a vaccine is put on hold.....

Damn, people are pretty fucked up when they seemingly jump for joy when a killing virus can last a little longer.
AFMadness
Inland Empire, CA
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Sep 10 2020 08:50AM     link to this

When Regan gave the Vaccine manufactures a free pass against future lawsuits you can afford to rush them to market since you have a grant of immunity from them.
sherkahn
Diamond Bar, SGV, LA, CA
Pomona, Inland Empire, CA Today!
1113 blogs/5529 comments
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Sep 10 2020 09:27AM     link to this

Let’s celebrate that incompetence and a rushed job was thwarted because it was more stunt than actual solution.

There other versions of the vaccine that seem to be following proper medical protocol.

So yay for getting medicine done right.
MMarblez
CA
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Sep 10 2020 10:53AM     link to this


I forgot you idiots try and politicize medicine lol.

How did it work last time you guys were developing a therapy?

Oh that's right, you just read articles and think you understand it
loucfirr1
LA, CA
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Sep 10 2020 11:42AM     link to this

+1
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